Abstract #1542

Noise Propagation of Variable Flip Angle T1 mapping with Emphasis on the Precision of RF Transmit Field Mapping

Yoojin Lee^1,2, Martina F. Callaghan³, and Zoltan Nagy¹

¹Laboratory for Social and Neural Systems Research, University of Zürich, Zürich, Switzerland, ²Institute for Biomedical Engineering, ETH Zürich, Zürich, Switzerland, ³Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

Rational approximation of the SPGR signal provides a simple algebraic expression of T₁ within the VFA framework. For this method, we derive an analytical solution of how the precision in T₁ maps depends on the noise in the B₁⁺ map as well as the component SPGR images. We show that the derived equation provides a good prediction of the noise in T₁ measured in-vivo. Further, we show that B₁⁺ maps can introduce as much noise into the T₁ maps as the SPGR images for equal input variance.

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