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Abstract #1542

Noise Propagation of Variable Flip Angle T1 mapping with Emphasis on the Precision of RF Transmit Field Mapping

Yoojin Lee1,2, Martina F. Callaghan3, and Zoltan Nagy1

1Laboratory for Social and Neural Systems Research, University of Zürich, Zürich, Switzerland, 2Institute for Biomedical Engineering, ETH Zürich, Zürich, Switzerland, 3Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

Rational approximation of the SPGR signal provides a simple algebraic expression of T1 within the VFA framework. For this method, we derive an analytical solution of how the precision in T1 maps depends on the noise in the B1+ map as well as the component SPGR images. We show that the derived equation provides a good prediction of the noise in T1 measured in-vivo. Further, we show that B1+ maps can introduce as much noise into the T1 maps as the SPGR images for equal input variance.

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