Abstract #1544

QUASAR: In vivo quantification of magnetic susceptibility in rodents

Ferdinand Schweser^1,2, Paul Polak¹, Nicola Bertolino¹, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

Despite increasing exploration of quantitative susceptibility mapping (QSM) in humans and the method's potential to study tissue iron pre-clinically, only few studies have yet applied QSM in alive rodents at ultra-high magnetic field strength. In the present work we hypothesized that the low quality of pre-clinical QSM compared to human QSM is due to the combination of a similar level of non-susceptibility phase contributions with much lower susceptibility variations. Here, we propose a new type of QSM algorithm that accounts for non-susceptibility phase effects and, hence, enables pre-clinical QSM: QUAntitative Susceptibility And Residual mapping (QUASAR).

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