Abstract #1551

The use of quantitative susceptibility imaging for the evaluation of acute MS lesion formation

Vanessa Wiggermann^1,2, Enedino Hernandez-Torres^2,3, Inga C Ibs⁴, Stephanie M Schoerner⁵, Galina Vorobeychik⁶, Luanne Metz⁷, David KB Li^8,9, Anthony Traboulsee^9,10, and Alexander Rauscher^2,9,11

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Pediatrics, University of British Columbia, Vancouver, BC, Canada, ³UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁴University of Osnabrueck, Osnabrueck, Germany, ⁵Technical University of Dortmund, Dortmund, Germany, ⁶Fraser Health MS Clinic, Burnaby, BC, Canada, ⁷Clinical Neurosciences, University of Calgary, Calgary, AB, Canada, ⁸Radiology, University of British Columbia, Vancouver, BC, Canada, ⁹Center for Brain Health, University of British Columbia, Vancouver, BC, Canada, ¹⁰Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ¹¹Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada

Using magnetic-susceptibility based MR techniques for the assessment of damage due to multiple sclerosis (MS) has been controversial, in particular in MS lesions where the underlying pathological changes are not yet fully understood. Here, we investigated the changes of the MR frequency and quantitative susceptibility signal during acute MS lesion formation. We observed that both metrics behave similarly, indicating that non-local effects have little contribution to the QSM signal increase and hence dipole inversion might not be required to assess damage during MS lesion formation accurately.

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