Probing the myelin water compartment with saturation recovery, multi-echo GE imaging at 7T

The purpose of this work was to investigate the microstructural properties of white matter in the human brain using saturation recovery multi-echo GE imaging at 7T.

Multi gradient-echo data acquired at three different flip-angles from 8 healthy subjects was fitted for corpus callosum to a three-pool model describing the axonal, myelin and external compartments and variation of the relative amplitude of the myelin water signal with flip-angle was used to assess the T₁ values of the different compartments. Results show an increased frequency variation with TE and faster magnitude signal decay at higher flip-angles, consistent with reduced T­₁ in the myelin water compartment.

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