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Abstract #1554

Probing the myelin water compartment with saturation recovery, multi-echo GE imaging at 7T

Elena Kleban1, Benjamin Tendler1, Penny Gowland1, and Richard Bowtell1

1The Sir Peter Mansfield Imaging Center, School of Physics and Astronomy, Nottingham, United Kingdom

The purpose of this work was to investigate the microstructural properties of white matter in the human brain using saturation recovery multi-echo GE imaging at 7T.

Multi gradient-echo data acquired at three different flip-angles from 8 healthy subjects was fitted for corpus callosum to a three-pool model describing the axonal, myelin and external compartments and variation of the relative amplitude of the myelin water signal with flip-angle was used to assess the T1 values of the different compartments. Results show an increased frequency variation with TE and faster magnitude signal decay at higher flip-angles, consistent with reduced T­1 in the myelin water compartment.

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