Sourajit Mitra Mustafi1, Paul R. Territo1, Brian P. McCarthy1, Amanda A. Riley1, Jiang Lei1, Chen Lin1, Qiuting Wen1, Bruce A Molitoris2, Gary D. Hutchins1, and Yu-Chien Wu1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States
In
this study, we used multi-shell diffusion-weighted imaging in an animal model
of Chronic Kidney Disease (CKD). We
focus on the functional changes in the kidney using diffusion tensor imaging
(DTI) and q-space imaging (QSI). Four Wistar
rats received surgical procedure to induce ischemic fibrosis in their left
kidney. The multi-shell
diffusion-weighted imaging was performed on the acute stage, day 2 after the
surgery. In the acute stage, the renal
medulla showed significant decrease in overall diffusivity measured by DTI and increase
in tissue restriction measured by q-space imaging.
