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Abstract #1580

Magnetic Resonance Diffusion Tensor and q-space imaging in an Animal Model of Chronic Kidney Disease.

Sourajit Mitra Mustafi1, Paul R. Territo1, Brian P. McCarthy1, Amanda A. Riley1, Jiang Lei1, Chen Lin1, Qiuting Wen1, Bruce A Molitoris2, Gary D. Hutchins1, and Yu-Chien Wu1

1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States

In this study, we used multi-shell diffusion-weighted imaging in an animal model of Chronic Kidney Disease (CKD). We focus on the functional changes in the kidney using diffusion tensor imaging (DTI) and q-space imaging (QSI). Four Wistar rats received surgical procedure to induce ischemic fibrosis in their left kidney. The multi-shell diffusion-weighted imaging was performed on the acute stage, day 2 after the surgery. In the acute stage, the renal medulla showed significant decrease in overall diffusivity measured by DTI and increase in tissue restriction measured by q-space imaging.

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