Abstract #1580

Magnetic Resonance Diffusion Tensor and q-space imaging in an Animal Model of Chronic Kidney Disease.

Sourajit Mitra Mustafi¹, Paul R. Territo¹, Brian P. McCarthy¹, Amanda A. Riley¹, Jiang Lei¹, Chen Lin¹, Qiuting Wen¹, Bruce A Molitoris², Gary D. Hutchins¹, and Yu-Chien Wu¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States

In this study, we used multi-shell diffusion-weighted imaging in an animal model of Chronic Kidney Disease (CKD). We focus on the functional changes in the kidney using diffusion tensor imaging (DTI) and q-space imaging (QSI). Four Wistar rats received surgical procedure to induce ischemic fibrosis in their left kidney. The multi-shell diffusion-weighted imaging was performed on the acute stage, day 2 after the surgery. In the acute stage, the renal medulla showed significant decrease in overall diffusivity measured by DTI and increase in tissue restriction measured by q-space imaging.

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