Meeting Banner
Abstract #1585

The effect of hyperbaric oxygen therapy on healthy and diabetic rat kidneys measured with hyperpolarised [1-13C]pyruvate

Thomas Stokholm Nørlinger1, Per Mose Nielsen1, Emmeli Mikkelsen1, Haiyun Qi1, Kasper Hansen2, Peter Kolstrup Agger3, Nikolaj Schmidt2, Michael Pedersen2, Hans Stødkilde-Jørgensen1, Frederik Palm4, and Christoffer Laustsen1

1Department of Clinical Medicine, MR Research Centre, Aarhus, Denmark, 2Department of Clinical Medicine, Comparative Medicine Lab, Aarhus, Denmark, 3Dept. of Cardiothoracic and Vascular Surgery, Aarhus, Denmark, 4Department of Medical and Health Sciences, Division of Drug Research, Linköping, Sweden

Hyperbaric oxygen therapy (HBO) is a well-known adjuvant treatment for several medical conditions indicated by the Undersea and Hyperbaric Medical Society. It is generally well tolerated and the kidneys display no adverse side effects after HBO. In diabetes hypoxia has been shown to be an important contributing factor in the development of diabetic nephropathy. In this experiment we investigate whether HBO has a protective effect on the kidney by preventing metabolic derangement as a consequence of hypoxia in the diabetic kidneys.

This abstract and the presentation materials are available to members only; a login is required.

Join Here