Abstract #1587

Tumour heterogeneity assessment using histogram analysis of IVIM-based diffusion and perfusion characteristics of cervical cancer

Jose Angelo Udal Perucho¹, Elaine Yuen Phin Lee¹, and Queenie Chan²

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong

Histogram analysis of intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DWI) could be a promising quantitative approach in assessing tumour heterogeneity. We retrospectively studied thirty-five treatment-naïve patients with cervical cancer who had IVIM MRI examinations to determine to the value of IVIM histogram analysis, as a means of assessing tumour heterogeneity, in relationship with clinical staging. We observed statistically significant differences in most histogram parameters of f (perfusion fraction) between patients with early and locally advanced disease but only three histogram parameters of D (true diffusion coefficient) were statistically different in patients with early and locally advanced cervical cancer.

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