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Abstract #1587

Tumour heterogeneity assessment using histogram analysis of IVIM-based diffusion and perfusion characteristics of cervical cancer

Jose Angelo Udal Perucho1, Elaine Yuen Phin Lee1, and Queenie Chan2

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong

Histogram analysis of intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DWI) could be a promising quantitative approach in assessing tumour heterogeneity. We retrospectively studied thirty-five treatment-naïve patients with cervical cancer who had IVIM MRI examinations to determine to the value of IVIM histogram analysis, as a means of assessing tumour heterogeneity, in relationship with clinical staging. We observed statistically significant differences in most histogram parameters of f (perfusion fraction) between patients with early and locally advanced disease but only three histogram parameters of D (true diffusion coefficient) were statistically different in patients with early and locally advanced cervical cancer.

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