Abstract #1595

Magnetic Resonance Spectroscopic Imaging (MRSI) Metabolite Ratio to Predict Malignancy in Patients with Prostate Cancer undergoing MRI-guided prostate biopsy

Juan C. Camacho^1,2, Nima Kokabi¹, Peter A. Harri¹, Tracy E. Powell², and Sherif G. Nour^1,2

¹Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Interventional MRI Program, Emory University Hospital, Atlanta, GA, United States

The study objective is to investigate Magnetic Resonance Spectroscopic Imaging (¹H-MRSI) in prostate lesions and to correlate the values with the results of MRI-guided prostate targeted sampling. A prospective cohort of patients presenting with persistently elevated or rising serum prostate specific antigen (PSA) and at least one lesion suspicious for prostate cancer that underwent MRI guided targeted biopsy was evaluated. Thirty-five consecutive patients were recruited presenting with 179 suspicious lesions. ROC curve analysis demonstrates a poor performance of ¹H-MRSI as a non-invasive imaging biomarker.

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