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Abstract #1598

To evaluate the damage of renal function in CIAKI rats at 3T: Using ASL and BOLD MRI

Yuhao Dong1, Wenbo Chen1, Long Liang1, Bin Zhang1, and Shuixing Zhang1

1Radiology, Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, Guangzhou, Guangzhou, China, People's Republic of

Contrast induced acute kidney injury (CIAKI) is a common complication after the administration of contrast media. The universally acknowledged mechanisms of CIAKI are the ischemia-mediated oxidative stress as well as the arteriolar vasoconstriction resulted from sustained contrast-induced, hypoxia in cortex and medulla. Our study aims to investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in different time points and different sites of kidney after contrast media administration. The results showed that ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI, which provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.

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