Yuhao Dong1, Wenbo Chen1, Long Liang1, Bin Zhang1, and Shuixing Zhang1
Contrast induced acute
kidney injury (CIAKI) is a common complication after the administration of
contrast media. The universally
acknowledged mechanisms of CIAKI are the ischemia-mediated oxidative stress as
well as the arteriolar vasoconstriction resulted from sustained
contrast-induced, hypoxia in cortex and medulla.
Our study aims to investigate noninvasive
arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD)
sequences for measuring renal hemodynamics and oxygenation in different time
points and different sites of kidney after contrast media administration. The results showed that
ASL combining BOLD can further identify the primary cause of the decrease of
renal oxygenation in CIAKI, which provides means for noninvasive monitoring
renal function during the first 4 days of CIAKI in clinical routine work.
