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Abstract #1623

Differentiating Early Stage and Later Stage Idiopathic Pulmonary Fibrosis using Hyperpolarized 129Xe Ventilation MRI

Mu He1, Scott H. Robertson2, Jennifer M. Wang3, Craig Rackley4, H. Page McAdams5, and Bastiaan Driehuys5

1Electrical and Computer Engineering Department, Duke University, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3School of Medicine, Duke University, Durham, NC, United States, 4Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States, 5Radiology, Duke University Medical Center, Durham, NC, United States

The use of 129Xe MRI to characterize ventilation has received little attention in IPF because these patients exhibit few ventilation defect regions (VDR) compared to those with other obstructive lung diseases. Here, we evaluate other aspects of the ventilation distribution by optimized linear binning. Ventilation distributions were quantified to provide not only VDR, but also low and high-intensity regions (LIR, HIR). We found that HIR was reduced by 3-fold in patients with late versus early stage disease, as measured by GAP IPF stage. Thus, loss of HIR may be a useful marker of disease progression in IPF.

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