Abstract #1623

Differentiating Early Stage and Later Stage Idiopathic Pulmonary Fibrosis using Hyperpolarized 129Xe Ventilation MRI

Mu He¹, Scott H. Robertson², Jennifer M. Wang³, Craig Rackley⁴, H. Page McAdams⁵, and Bastiaan Driehuys⁵

¹Electrical and Computer Engineering Department, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³School of Medicine, Duke University, Durham, NC, United States, ⁴Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, United States, ⁵Radiology, Duke University Medical Center, Durham, NC, United States

The use of ¹²⁹Xe MRI to characterize ventilation has received little attention in IPF because these patients exhibit few ventilation defect regions (VDR) compared to those with other obstructive lung diseases. Here, we evaluate other aspects of the ventilation distribution by optimized linear binning. Ventilation distributions were quantified to provide not only VDR, but also low and high-intensity regions (LIR, HIR). We found that HIR was reduced by 3-fold in patients with late versus early stage disease, as measured by GAP IPF stage. Thus, loss of HIR may be a useful marker of disease progression in IPF.

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