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Abstract #1637

Which is more favorable surrogate marker to predict liver fibrosis on Gd-EOB-DTPA enhanced MRI at 1.5T, ADC value on diffusion weighted imaging or quantitative enhancement ratio?

Taiyou Leopoldo Harada1, Kazuhiro Saito1, Yoichi Araki1, Jun Matsubayashi2, Toshitaka Nagao2, and Koichi Tokuuye1

1Radiology, Tokyo Medical University Hospital, Shinjuku-ku, Japan, 2Pathology, Tokyo Medical University Hospital, Shinjuku-ku, Japan

This study is to evaluate which is favorable surrogate marker to predict the liver fibrosis, DWI or quantitative enhancement ratio measured at hepatobiliary phase on Gd-EOB-DTPA enhanced-MRI. Eighty-three patients with 99 lesions were enrolled. ADC was measured at a distance of 5-10 mm from the tumor. Liver-to-muscle ratio (LMR), liver-to-spleen ratio (LSR) and contrast enhancement index (CEI) were calculated. ADC showed no significant difference among fibrosis grades. LMR and CEI showed significant differences between high stage and low stage fibrosis group (p<0.01 and p=0.04). In conclusion, LMR was best surrogate parameters to distinguish high stage from low stage fibrosis.

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