Abstract #1662

Simultaneous PET/MR/EEG to study brain connectivity on different physiological and temporal scales in epilepsy patients

Andre Thielcke¹, Adham Elshahabi², Ilja Bezrukov¹, Suril Gohel³, Mario Amend¹, Holger Schmidt⁴, Matthias Reimold⁵, Holger Lerche², Bharat Biswal³, Bernd J. Pichler¹, Niels Focke², Christian la Fougère⁵, and Hans F. Wehrl¹

¹Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University of Tuebingen, Tuebingen, Germany, ²Neurology & Epileptology and Werner Reichardt Centre for Integrative Neuroscience, Eberhard Karls University of Tuebingen, Tuebingen, Germany, ³Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States, ⁴Interventional and Diagnostic Radiology, Eberhard Karls University of Tuebingen, Tuebingen, Germany, ⁵Nuclear Medicine and Werner Reichardt Centre for Integrative Neuroscience, Eberhard Karls University of Tuebingen, Tuebingen, Germany

Simultaneous PET/MR/EEG was used in humans to study brain networks in the resting state on slow, medium and fast time scales. We found that the representation of the default mode network (e.g. in terms of correlation between regions) varies between modality and time scale applied. However, for the DMN as well as other networks similarities but also differences between modalities were seen. This work opens the domain for studying brain activity on different physiological (metabolic, hemodynamic and electric) but also on different time scales.

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