Abstract #1674

Longitudinal Study of Motor Recovery After Pontine Infarction with Resting-state fMRI：A Homotopic Connectivity Study

Yi Shan¹, Chaogan Yan², Miao Zhang¹, Dongdong Rong¹, Zhilian Zhao¹, Qingfeng Ma³, Xinian Zuo², Jie Lu⁴, and Kuncheng Li¹

¹Department of Radiology, Xuanwu hospital, Capital Medical University, Beijing, China, People's Republic of, ²Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, People's Republic of, ³Department of Neurology, Xuanwu hospital, Capital Medical University, Beijing, China, People's Republic of, ⁴Department of Nuclear Medicine, Xuanwu hospital, Capital Medical University, Beijing, China, People's Republic of

Impairment of motor function is one of the most severe deficit in ischemic stroke patients. Therefore, evaluations of brain function reorganization during spontaneous motor recovery are extremely valuable. In the present study, we used a voxel-mirrored homotopic connectivity (VMHC) method to investigate the longitudinal functional homotopic changes in patients with pontine infarction during a 180-day-period follow-up. The result shows resting-state fMRI could demonstrate dynamic whole-brain homotopic FC changes in stroke patients which might be helpful to further discuss brain reorganization after stroke. Also, VMHC between cognitive brain areas in acute stage had significant correlation with clinical behavioral performance in chronic period which might be meaningful in predicting motor outcome.

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