Abstract #1702

Modular Reorganization of Resting-State Brain Network in Patients with Obstructive Sleep Apnea

Bumhee Park¹, Sudhakar Tummala¹, Ruchi Vig¹, Daniel W Kang², Mary A Woo³, and Rajesh Kumar^1,4,5,6

¹Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ³UCLA School of Nursing, Los Angeles, CA, United States, ⁴Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States

Obstructive sleep apnea (OSA) condition is accompanied by brain tissue injury and functional deficits in regions serving autonomic, neuropsychologic, and cognitive functions. Brain networks are organized into modular systems and assigning vulnerable role for each region in terms of intra- and inter-modular communication provides better understanding for functional deficits in the condition. We examined the modular reorganization of OSA functional networks, and found abnormal intra- and/or inter-modular communication roles in brain regions involved in autonomic, neuropsychologic, and cognitive regulation. The findings suggest that dysfunctions associated with OSA may be related to abnormal information flow, and can be examined with modular reorganization assessment.

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