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Abstract #1708

Intrinsic functional connectivity in patients with presbycusis

Fei Gao1, Guangbin Wang1, Bin Zhao1, Muwei Li2, Fuxin Ren1, and Weibo Chen3

1Shandong Medical Imaging Research Institute, Shandong University, JINAN, China, People's Republic of, 2College of Electronics and Information Engineering, Sichuan University, Chengdu, China, People's Republic of, 3Philips Healthcare, Shanghai, China, People's Republic of

Presbycusis is the most common sensory deficit in the ageing population. However, little is known about whether the topological properties of brain functional networks is disrupted in patients with presbycusis. Our study demonstrates decreased clustering coefficient, local efficiency and strength in the primary auditory cortex in patients with presbycusis, as compared to age- and gender-matched healthy controls. Our study provides evidence of presbycusis-related disruptions in brain functional networks in patients with presbycusis. It is believed that our findings could be important for exploring functional changes in the central presbycusis.

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