Abstract #1710

Subregion-specific Resting-State Amygdala Connectivity in Chronic Knee Osteoarthritis Pain: Towards a brain network signature of OA pain

William J Cottam^1,2,3, Marianne Drabek^1,2,3, Diane Reckziegel^1,2,3, and Dorothee P Auer^1,2,3

¹Division of Clinical Neuroscience, Radiological Sciences, University of Nottingham, Nottingham, United Kingdom, ²ARUK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ³Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Brain network connectivity analysis arguably offers the most sensitive marker to detect dysfunctional brain plasticity underlying the maladaptive nature of chronic pain. Early functional connectivity (fc) studies reveal altered functional connectivity in chronic pain states, but to the best of our knowledge no studies have focussed upon the amygdala. We aimed to investigate whether patients with painful chronic knee OA show altered amygdala connectivity compared to pain-free controls.This study identified increased functional connectivity of specific amygdala subnuclei in chronic OA pain patients compared to healthy subjects.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.