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Abstract #1710

Subregion-specific Resting-State Amygdala Connectivity in Chronic Knee Osteoarthritis Pain: Towards a brain network signature of OA pain

William J Cottam1,2,3, Marianne Drabek1,2,3, Diane Reckziegel1,2,3, and Dorothee P Auer1,2,3

1Division of Clinical Neuroscience, Radiological Sciences, University of Nottingham, Nottingham, United Kingdom, 2ARUK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Brain network connectivity analysis arguably offers the most sensitive marker to detect dysfunctional brain plasticity underlying the maladaptive nature of chronic pain. Early functional connectivity (fc) studies reveal altered functional connectivity in chronic pain states, but to the best of our knowledge no studies have focussed upon the amygdala. We aimed to investigate whether patients with painful chronic knee OA show altered amygdala connectivity compared to pain-free controls.This study identified increased functional connectivity of specific amygdala subnuclei in chronic OA pain patients compared to healthy subjects.

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