Abstract #1712

Demonstration of brain tumor-induced abnormalities on regional homogeneity (ReHo) resting state fMRI metrics KCC-ReHo & Cohe-ReHo

Shruti Agarwal¹, Noushin Yahyavi-Firouz-Abadi¹, Haris I. Sair¹, Raag Airan¹, and Jay J. Pillai¹

¹Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Disruption of the normal coupling between neural activity and the consequent microvascular blood flow response (neurovascular uncoupling or NVU) may severely compromise the validity of BOLD fMRI in presurgical planning. The effects of brain tumor-related NVU on resting state BOLD fMRI (rsfMRI) using functional connectivity analysis have been previously published. In this study we evaluated regional homogeneity (ReHo) of rsfMRI data based on Kendall's coefficient of concordance (KCC-ReHo) & Coherence (Cohe-ReHo) and compared the results with the amplitude of low-frequency fluctuation (ALFF) & standard motor tbfMRI activation to investigate regional abnormalities due to brain tumor-induced NVU in sensorimotor network.

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