The effect of plasma-dissolved oxygen on the hyperoxic calibrated BOLD signal: a simulation study using the detailed BOLD model
Yuhan Ma1, Avery Berman1, and G. Bruce Pike1,2
1Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 2Department of Radiology, Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, AB, Canada
It has been suggested
that during a hyperoxic calibration, the paramagnetic
oxygen dissolved in arterial blood plasma can be a confounding factor for the
interpretation of the calibrated BOLD signal. In this study, we aimed to predict the relative
effect of dissolved oxygen on hyperoxic BOLD signal by expanding the detailed BOLD model with the effect of dissolved oxygen. Our
results showed minimal difference in both the relative BOLD signal and the
calibration parameter calculated with the effect of dissolved oxygen. Therefore,
the influence of the dissolved oxygen in arterial blood plasma on the measured
calibrated BOLD signal at 3 T can generally be ignored.
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