Abstract #1718

The effect of plasma-dissolved oxygen on the hyperoxic calibrated BOLD signal: a simulation study using the detailed BOLD model

Yuhan Ma¹, Avery Berman¹, and G. Bruce Pike^1,2

¹Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ²Department of Radiology, Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, AB, Canada

It has been suggested that during a hyperoxic calibration, the paramagnetic oxygen dissolved in arterial blood plasma can be a confounding factor for the interpretation of the calibrated BOLD signal. In this study, we aimed to predict the relative effect of dissolved oxygen on hyperoxic BOLD signal by expanding the detailed BOLD model with the effect of dissolved oxygen. Our results showed minimal difference in both the relative BOLD signal and the calibration parameter calculated with the effect of dissolved oxygen. Therefore, the influence of the dissolved oxygen in arterial blood plasma on the measured calibrated BOLD signal at 3 T can generally be ignored.

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