Abstract #1723

fMRI study of the role of glutamate NMDA receptor in olfactory habituation of olfactory bulb and higher olfactory structures in rats

Fuqiang Zhao¹, Xiaohai Wang², Hatim A Zariwala², Jason M. Uslaner², Andrea K Houghton², Jeffrey L Evelhoch¹, Eric Hostetler¹, and Catherine Diane Gard Hines¹

¹Imaging, Merck Co. & Inc., West Point, PA, United States, ²Neuroscience, Merck Co. & Inc., West Point, PA, United States

fMRI offers an excellent opportunity to study olfactory processing in different olfactory structures. Measurement of the magnitude of odor stimulation-induced activations, and their suppression with agonist/antagonist of different neural receptors can provide important information to understand the mechanism of olfactory habituation. In this study, cerebral blood volume (CBV) fMRI with USPIO was used to measure odorant-induced olfaction in different olfactory structures of rats. The dynamics of habituation in different olfactory structures can be robustly measured by fMRI. MK801 can reverse habituated olfactory responses in all olfactory structures, suggesting that glutamate/NMDA receptor plays a major role in olfactory habituation.

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