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Abstract #1732

Inter-hemispheric functional dysconnectivity mediates the effect of corpus callosum degeneration on memory impairment in AD and amnestic MCI

Yingwei Qiu1, Siwei Liu1, Saima Hilal2, Yng Miin Loke1, Mohammad Kamran Ikram3, Xin Xu2, Boon Yeow Tan4, Narayanaswamy Venketasubramanian5, Christopher Li-Hsian Chen 2, and Juan Zhou1,6

1Multimodal Neuroimaging in Neuropsychiatric Disorders Laboratory, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore, 2Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore, Singapore, 3Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore, 4St. Luke’s Hospital, Singapore, Singapore, 5Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore, 6Clinical Imaging Research Centre, Technology and Research and National University of Singapore, Singapore, Singapore

The cognitive significance of corpus callosumdegeneration and the related functional connectivity changes in AD and amnestic MCIremains largely unknown. Our study attempted to fill this gap of knowledge by examininghow selective structural degeneration in CC was associated with memory impairment andwhether such relationship was influenced by inter-hemispheric homotopic functionaldysconnectivity in AD and amnestic MCI.

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