Abstract #1732

Inter-hemispheric functional dysconnectivity mediates the effect of corpus callosum degeneration on memory impairment in AD and amnestic MCI

Yingwei Qiu¹, Siwei Liu¹, Saima Hilal², Yng Miin Loke¹, Mohammad Kamran Ikram³, Xin Xu², Boon Yeow Tan⁴, Narayanaswamy Venketasubramanian⁵, Christopher Li-Hsian Chen ², and Juan Zhou^1,6

¹Multimodal Neuroimaging in Neuropsychiatric Disorders Laboratory, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore, ²Department of Pharmacology, National University Health System, Clinical Research Centre, Singapore, Singapore, ³Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore, ⁴St. Luke’s Hospital, Singapore, Singapore, ⁵Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore, ⁶Clinical Imaging Research Centre, Technology and Research and National University of Singapore, Singapore, Singapore

The cognitive significance of corpus callosumdegeneration and the related functional connectivity changes in AD and amnestic MCIremains largely unknown. Our study attempted to fill this gap of knowledge by examininghow selective structural degeneration in CC was associated with memory impairment andwhether such relationship was influenced by inter-hemispheric homotopic functionaldysconnectivity in AD and amnestic MCI.

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