Abstract #1740

fMRI characterization of pain processing in NaV1.7 Wnt1 KO mice

Giovanna Diletta Ielacqua¹, Aileen Schroeter¹, David Bühlmann ^1,2, Felix Schlegel^1,2, John N Wood³, and Markus Rudin^1,4

¹Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, ²Neuroscience Center Zurich, Zurich, Switzerland, ³Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom, ⁴Institute of pharmacology and toxicology, Univeristy of Zurich, Zurich, Switzerland

Stimulus-evoked fMRI (se-fMRI) measurements in mice have turned out difficult, and so far it is under investigation whether and how se-fMRI applications can yield to reliable and robust readouts. Generally, se-fMRI could be a useful tool to study how the brain processes innocuous and noxious stimuli, i.e. to characterize genetically modified mouse strains, such as mice exhibiting impaired nociception. In this study, NaV1.7-Wnt1 KO mice are characterized with respect to neural processing of different types and strengths of peripheral stimuli and compared to a WT control group. Results of behavioral tests are compared to outcomes of fMRI measurements.

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