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Abstract #1740

fMRI characterization of pain processing in NaV1.7 Wnt1 KO mice

Giovanna Diletta Ielacqua1, Aileen Schroeter1, David B├╝hlmann 1,2, Felix Schlegel1,2, John N Wood3, and Markus Rudin1,4

1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2Neuroscience Center Zurich, Zurich, Switzerland, 3Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom, 4Institute of pharmacology and toxicology, Univeristy of Zurich, Zurich, Switzerland

Stimulus-evoked fMRI (se-fMRI) measurements in mice have turned out difficult, and so far it is under investigation whether and how se-fMRI applications can yield to reliable and robust readouts. Generally, se-fMRI could be a useful tool to study how the brain processes innocuous and noxious stimuli, i.e. to characterize genetically modified mouse strains, such as mice exhibiting impaired nociception. In this study, NaV1.7-Wnt1 KO mice are characterized with respect to neural processing of different types and strengths of peripheral stimuli and compared to a WT control group. Results of behavioral tests are compared to outcomes of fMRI measurements.

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