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Abstract #1775

Joint Estimation of Attenuation and Activity Distributions for Clinical non-TOF FDG Head Patient PET/MR Data Employing MR Prior Information

Thorsten Heußer1, Christopher M Rank1, Martin T Freitag2, Heinz-Peter Schlemmer2, Antonia Dimitrakopoulou-Strauss3, Thomas Beyer4, and Marc Kachelrieß1

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Vienna, Austria

To improve attenuation correction (AC) and thus PET quantification for PET/MR imaging, we have recently proposed a method to jointly estimate attenuation and activity distributions from the non-TOF PET emission data. Available MR information is used to derive voxel-specific expectations on the attenuation coefficients, favoring the occurrence of pre-selected attenuation values corresponding to air, soft tissue, and bone. We here present first results for clinical non-TOF 18F-FDG PET/MR data sets of the head region. PET reconstruction was performed using MR-based AC as provided by the vendor, our proposed algorithm, and CT-based AC for comparison.

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