Abstract #1815

4D flow MRI of the cardiovascular system in small animals at 7T with an Ultrashort TE sequence combined with an injection of iron nanoparticle

Aurelien J Trotier¹, Charles R CASTETS¹, William LEFRANCOIS¹, Emeline J RIBOT¹, Eric THIAUDIERE¹, Jean-Michel FRANCONI¹, and Sylvain MIRAUX¹

¹RMSB-UMR5536, CNRS - Université de Bordeaux, Bordeaux, France

4D flow MRI on mouse models remains very difficult due to the very small size of vessels and the extremely high cardiac rhythm. To overcome this problem a 3D time-resolved Phase Contrast UTE sequence was combined with an injection of Ultra Small Particles of Iron Oxide to obtain a positive and high signal in blood. The method was exploited to quantify blood flow velocity of the cardiovascular system in mice with a high spatial (200 µm)3 and temporal resolution (16ms). The total acquisition can be reduced to 25min by limiting the number of acquired projections per cine image.

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