Abstract #1836

Quantitative analysis of the volume and lipid content of liver and spleen using Dual-echo mDixon sequence and T2WI-STIR sequences in child and adolescent patients with gaucher disease

Xiaojuan TAO¹, Yun PENG¹, Yanqiu LV¹, and Kaining SHI²

¹Imaging Center of Beijing Children's Hospital Affiliated To Capital Medical University, Beijing, China, People's Republic of, ²Imaging Systems Clinical Science Philips Healthcare, Beijing, China, People's Republic of

Spleen and liver are common organs involved in Gaucher disease (GD), while few reports have been published on the measurement of volume and lipid content of liver and spleen using MR. This study recruited 42 patients with GD by 1.5T MR. Our results showed that enlargement of spleen was more severe than liver. Spleen has higher lipid content than liver among these patients, while both of them exhibited higher fat fraction than normal value. Our study suggests MRI can be employed to monitor the disease progression and effect of the treatment in children and adolescent patients with GD.

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