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Abstract #1846

Brain pulsatility across the cardiac cycle revealed by cine 3D integrated-SSFP

Lirong Yan1, Mayank Jog1, Kay Jann1, Xingfeng Shao1, and Danny JJ Wang1

1Neurology, University of California Los Angeles, Los Angeles, CA, United States

The alternations of brain pulsatility are related to various pathological changes such as traumatic brain injury (TBI) and brain tumor. In the present study, we introduced a new MRI approach to assess the brain’s biomechanical features using ECG-gated cine 3D integrated-SSFP, which offers dynamic 3D brain volumes with high spatial resolution. The voxel-wise deformation was derived from jacobian maps over the cardiac cycle. We found that greater deformation in the brain occurs in basal ganglia and brain stem, and then attenuates toward the white matter and brain cortex during the cardiac cycle.

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