Abstract #1905

Toward a voxel-based analysis (VBA) of quantitative magnetic susceptibility maps (QSM): Strategies for creating brain susceptibility templates

Jannis Hanspach¹, Michael G Dwyer¹, Niels P Bergsland^1,2, Xiang Feng³, Jesper Hagemeier¹, Paul Polak¹, Nicola Bertolino¹, Jürgen R Reichenbach^3,4, Robert Zivadinov^1,5, and Ferdinand Schweser^1,5

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MR Research Laboratory, IRCCS Don Gnocchi Foundation ONLUS, Milan, Italy, ³Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ⁴Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, ⁵MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

Quantitative susceptibility mapping (QSM) is a recent in vivo magnetic resonance imaging (MRI) technique that provides quantitative information about the bulk magnetic susceptibility distribution in tissues, a promising measure for studying brain iron. A voxel-based analysis (VBA) of susceptibility maps would facilitate a better understanding of the intricate anatomical structure (e.g. sub-nuclear regions) of deep gray matter and its relation to diseases and normal aging.

In the present work, we developed and quantitatively assessed six strategies for creating a susceptibility brain template for VBA based on ANTs, representing the first step toward an understanding of sub-nuclear susceptibility changes without the need for a priori information.

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