Abstract #1932

Dynamic Contrast Enhanced MRI Measurements in Glioma: Comparison Between Two Models

Sameeha Fallatah¹, Rolf Jäger¹, and Xavier Golay¹

¹Brain Repair and Rehabilitation, UCL, Institute of Neurology, London, United Kingdom

Dynamic Contrast Enhanced MRI is used to assess the integrity of the blood brain barrier. A major difficulty for the method to be accepted in the clinics is the variety of pharmacokinetic models used and their strong dependence on the underlying assumptions and/or acquisition parameters. Thus the far simpler methods based on signal intensity curve characteristics are the most commonly used approaches in clinical practice. In this study we compare two different pharmacokinetic models, the extended Tofts model and Lawrence & Lee model in patients with primary brain tumours.

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