Abstract #1935

Regional Brain Tissue Entropy Assessment in Patients with Obstructive Sleep Apnea

Sudhakar Tummala¹, Bumhee Park¹, Ruchi Vig¹, Mary A Woo², Daniel W Kang³, Ronald M Harper^4,5, and Rajesh Kumar^1,5,6,7

¹Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, Los Angeles, CA, United States, ³Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Neurobiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

Obstructive sleep apnea subjects show gray matter volume loss in multiple brain areas, based on voxel-based morphometry procedures, which are less sensitive in detecting subtle chronic/acute gray or white matter changes. We assessed brain injury in recently-diagnosed, treatment naïve OSA subjects by evaluating regional entropy, which measures the extent of homogeneity or randomness in tissue texture, and found significantly decreased regional entropy values in areas regulating autonomic, respiratory, cognitive, and neuropsychologic functions that are deficient in the condition, suggesting predominantly acute tissue pathology in those sites.. The findings suggest that regional entropy can demonstrate acute tissue changes.

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