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Abstract #1938

Characterization of atherosclerotic carotid plaque using MATCH with histopathologic validation: initial clinical experience

Lixin Yang1, Wei Yu1, Zhaoyang Fan2, and DeBiao Li3

1Department of Radiology, Beijing AnZhen Hospital, Beijing, China, People's Republic of, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Biomedical Imaging Research Institute, Cedars-Sinai Medical Center,Department of Bioengineering, University of California, Los Angeles, CA, United States

Purpose: Determine the accuracy of MATCH in the characterization of plaque composition in patients in comparison with the conventional multi-contrast approach, using histopathology as the gold standard.

Methods: Twenty-two patients scheduled for carotid endarterectomy underwent preoperative carotid MRI with MATCH and the conventional protocol, blinded image review for composition identification was performed by 2 radiologists. Carotid histopathological specimens stained with HE and Masson, matched with this two protocol images, Cohen kappa (K) was computed to quantify the agreement in the detection of components among this two protocols and histopathology.

Results: Moderate to good agreement was seen between histopathological specimens and multi-contrast protocol in the detection of plaque components (IH k=0.704 , CA k=0.763, LR/NC k=0.844). Similar results were seen between histopathological specimens and MATCH (IH k=0.703CA k=0.740, LR/NC k=0.850).

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