Abstract #1941

The Influence of Bolus Arrival Time in Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI of Breast Masses

Endre Grøvik^1,2, Atle Bjørnerud^1,2, Tryggve Holck Storås¹, Kjell-Inge Gjesdal³, and Kathinka Dæhli Kurz⁴

¹The Intervention Centre, Oslo University Hospital, Oslo, Norway, ²Department of Physics, University of Oslo, Oslo, Norway, ³Sunnmøre MR klinikk AS, Ålesund, Norway, ⁴Department of Radiology, Stavanger University Hospital, Stavanger, Norway

The purpose was to evaluate the influence of BAT in pharmacokinetic analysis of breast masses, by estimating the kinetic parameters both with and without BAT-delay correction. Thirty-nine verified breast masses were examined using a high temporal resolution EPI sequence. The image-data were analyzed using a two-compartment kinetic model with and without BAT-delay correction. The relationship between the relative parametric error and BAT-delay were investigated. The result indicates that neglecting the delayed BAT leads to an overestimation of K^trans, k_ep, and, v_e, and a underestimation of v_p, and that the delayed BAT needs to be accounted for in the model-based analysis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.