Abstract #1956

Noise-robust multifrequency wave number inversion for high-resolution MR elastography in the abdomen

Heiko Tzschätzsch¹, Jing Guo¹, Florian Dittmann¹, Sebastian Hirsch¹, Eric Barnhill¹, Jürgen Braun², and Ingolf Sack¹

¹Department of Radiology, Charité - University Medicine Berlin, Berlin, Germany, ²Institute of Medical Informatics, Charité - University Medicine Berlin, Berlin, Germany

Elastography often suffers from limited anatomical resolution due to noise and insufficient elastic deformation. We here introduce noise-robust multifrequency wave number inversion for multifrequency MR elastography. Compound maps of wave speed are obtained, which reveal variations in tissue elasticity in a tomographic fashion, i.e. an unmasked, slice-wise display of anatomical details at pixel-wise resolution. The method is demonstrated using data from the literature including abdominal and pelvic organs such as the liver, spleen, uterus and cervix. Elastic parameters consistent with literature values were obtained even in small regions with low wave amplitudes such as nucleus pulposus and spinal cord.

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