Abstract #1961

Poroelastic mechanical properties of brain tumors using intrinsic actuation MR elastography

Ligin Solamen¹, Matthew McGarry¹, Elijah Van Houten², Jennifer Hong³, John Weaver^1,4, and Keith Paulsen^1,5

¹Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, ²Department of Mechanical Engineering, University of Sherbrooke, Sherbrooke, QC, Canada, ³Department of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States, ⁴Department of Radioogy, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States, ⁵Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States

Intrinsically actuated poroelastic MR elastography (IA-pMRE) is a technique which estimates tissue mechanical and hydrodynamic properties using measurements of displacement during the cardiac cycle, and does not require external vibration as in traditional MRE. Compared to conventional MRE, which obtains displacements in the range of 25-100Hz, IA-pMRE uses intrinsically generated low frequency (1-2Hz) displacements for elastography reconstruction. IA-pMRE was applied to 7 brain tumor patients and showed a significant difference in both the shear modulus and hydraulic conductivity of brain tissue compared to healthy tissue.

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