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Abstract #1966

Exploring the impact of common sequence variations on ADC reliability of lung lesions prior to protocol implementation in multi-centre clinical trials

Marianthi-Vasiliki Papoutsaki1, Alex Weller1, Matthew R Orton1, and Nandita M de Souza1

1Radiotherapy and Imaging, The Institute of Cancer Research, Sutton, London, United Kingdom

Standardization of diffusion-weighted (DW) protocols in multi-centre clinical trials is challenging. Prior to protocol development, the effect of inter-vendor related sequence variations on the apparent diffusion coefficient (ADC) reliability should be explored. In this study, the reliability of ADC estimates of lung lesions using two optimised DW protocols was assessed by mimicking vendor-related sequence variations. Patients with lung lesions were scanned twice using two DW protocols with different fat suppression techniques, diffusion gradient modes and TEs. These key variations increased the coefficient of variation of the ADC estimates of lung lesions, although absolute values did not differ significantly.

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