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Abstract #1992

Characterization of Brain White Matter Tissue Structure with Double-Diffusion-Encoded MRI

Yasar Goedecke1 and J├╝rgen Finsterbusch1

1Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Double-diffusion-encoding (DDE) or double-wave-vector (DWV) experiments show a signal behavior that is specific for restricted diffusion. Thus, these experiments could provide more direct insight into tissue microstructure than conventional experiments, especially when targeting axon diameters. In this study, a previous DDE-based approach to estimate axon diameters is extended (i) to be applicable without prior knowledge of the fiber orientation, (ii) by considering a more complex tissue composition including spherical cells and an unrestricted compartment to model glial cells and extracellular space, and (iii) using the multiple correlation function framework that provides a more accurate approximation of the MR signal.

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