Abstract #2003

Inferring axon diameter from the apparent cylindrical geocentric diameter in the longitudinal plane

Farshid Sepehrband¹ and Kristi A Clark¹

¹Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, CA, United States

Recent diffusion-weighted imaging techniques have enabled the inference of axon diameter, a valuable neuroanatomical measure^1,2. Current techniques fit a cylindrical model of axons to the acquired signal, primarily in the transverse direction. Despite many improvements, sensitivity to small axons is difficult to achieve, primarily due to the scanner’s physical limitations. Even with a strong gradient strength system such as the connectome scanner and high SNR, the minimum resolvable axon diameters are greater than 2μm, which accounts for only a small proportion of axons in the human brain. Here we utilize Neuman’s cylindrical model³, and generalize it to the geocentric direction in the longitudinal plane of axons (Figure 1) to decrease the minimum axon diameter resolvable with a given scanner.

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