Abstract #2018

Maximum b-value dependence of Diffusion kurtosis imaging sensitivity in detecting white matter microstructure

Miao Sha¹, Yuanyuan Chen¹, Xin Zhao¹, Man Sun², Weiwei Wang¹, Hongyan Ni², and Dong Ming¹

¹Tianjin University, Tianjin, China, People's Republic of, ²Tianjin First Center Hospital, Tianjin, China, People's Republic of

Diffusion kurtosis imaging is a powerful technique to measure the non-gaussion diffusion as well as the complicated microstructure. In this paper, we conducted a comparison between different acquisitions with different maximum b-value on normal volunteers. We found that the outcome of diffusion kurtosis imaging was influenced by the maximum b-value in the acquisition. And this influence was highly associated with the microstructure, including both radial profile and angular profile in the structure reconstruction, which indicated the mechanism of non-gaussion under high b-value.

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