Meeting Banner
Abstract #2031

Oscillating Gradient Spin Echo Diffusion Tensor MRI of the Brain in Multiple Sclerosis Patients

Christian Beaulieu1, Corey Baron1, Penny Smyth2, Roxane Billey2, Leah White2, Fabrizio Giuliani1, Derek Emery3, and Robert Stobbe1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada, 3Radiology, University of Alberta, Edmonton, AB, Canada

In diffusion tensor imaging, oscillating gradient spin echo (OGSE) gradient waveforms enable much shorter diffusion times (4 ms) than the typical pulsed gradient spin echo (PGSE, 40 ms) and OGSE was applied here for the first time in multiple sclerosis patients. A different dependence on diffusion time would suggest a change in micro-structural scale within the MS lesions. Compared to normal appearing white matter (NAWM), FLAIR-visible lesions showed reductions of fractional anisotropy (FA) on both PGSE and OGSE. The proportional FA decrease between NAWM and lesions was similar for OGSE and PGSE.

This abstract and the presentation materials are available to members only; a login is required.

Join Here