Abstract #2031

Oscillating Gradient Spin Echo Diffusion Tensor MRI of the Brain in Multiple Sclerosis Patients

Christian Beaulieu¹, Corey Baron¹, Penny Smyth², Roxane Billey², Leah White², Fabrizio Giuliani¹, Derek Emery³, and Robert Stobbe¹

¹Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Neurology, University of Alberta, Edmonton, AB, Canada, ³Radiology, University of Alberta, Edmonton, AB, Canada

In diffusion tensor imaging, oscillating gradient spin echo (OGSE) gradient waveforms enable much shorter diffusion times (4 ms) than the typical pulsed gradient spin echo (PGSE, 40 ms) and OGSE was applied here for the first time in multiple sclerosis patients. A different dependence on diffusion time would suggest a change in micro-structural scale within the MS lesions. Compared to normal appearing white matter (NAWM), FLAIR-visible lesions showed reductions of fractional anisotropy (FA) on both PGSE and OGSE. The proportional FA decrease between NAWM and lesions was similar for OGSE and PGSE.

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