Abstract #2045

White matter microstructural deficits in schizophrenia using generalized kurtosis

Arash Nazeri¹, Lipeng Ning², Jon Pipitone¹, David J. Rotenberg¹, Yogesh Rathi², and Aristotle N. Voineskos¹

¹Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Numerous studies have used diffusion tensor imaging to investigate schizophrenia-related white matter microstructural deficits. Diffusion tensor imaging assumes a Gaussian distribution for the water molecule displacement. However, this assumption may not be valid in the complex biological tissues such as white matter. Using directional radial basis function it is possible to estimate ensemble average diffusion propagator and generalized kurtosis of water diffusion (a measure of non-Gaussianity). Our results suggest that white matter generalized kurtosis is more sensitive to differences between persons with schizophrenia and healthy controls than diffusion tensor model parameters (particularly in frontotemporal superficial white matter areas).

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