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Abstract #2048

Correcting spatial misalignment between fiber bundles segments for along-tract group analysis

Samuel St-Jean1, Max Viergever1, Geert Jan Biessels2, and Alexander Leemans1

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, Netherlands

For diffusion MRI studies relying on statistics computed along fiber trajectories, the extracted values might not be optimally aligned between subjects in the metric space, which could lead to subsequent erroneous statistical analysis. We thus propose a 1D fast Fourier transform based correction algorithm for a fast realignment (< 1 second) directly in the metric space. Our experiments with a) synthetic signals and b) FA values along the uncinate fasciculus from real data show that our fiber-tract realignment algorithm improves the overlap of extracted metrics. This could help researchers uncover relationships of interest which were hidden by residual misalignment at first.

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