Abstract #2070

Individualized prediction of schizophrenia based on patterns of altered tract integrity over the whole brain using diffusion spectrum imaging

Yu-Jen Chen¹, Chih-Ming Liu², Tzung-Jeng Huang², Yun-Chin Hsu¹, Yu-Chun Lo¹, Hai-Gwo Hwu², and Wen-Yih Isaac Tseng^1,3

¹National Taiwan University, Institute of Medical Device and Imaging, Taipei, Taiwan, ²National Taiwan University Hospital, Department of Psychiatry, Taipei, Taiwan, ³National Taiwan University, Molecular Imaging Center, Taipei, Taiwan

In this study, we examined the performance of predicting patients with schizophrenia based on the patterns of altered tract integrity over the whole brain. The whole-brain tract information was compared with predefined differences between schizophrenia patients and healthy participants to calculate an index of SLI indicating the similarity to schizophrenia. Our results showed that the prediction performance was high (AUC = 0.86 for males; AUC = 0.77 for females) when we compared the white matter integrities at specific segments on fiber pathways.

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