Abstract #2079

Sensitivity of diffusion metrics in complex white matter configurations

Pedro Angel Luque Laguna^1,2, Luis Lacerda^1,2, Steve C.R. Williams¹, and Flavio Dell'Acqua^1,2

¹Neuroimaging, King's College London, LONDON, United Kingdom, ²Natbrainlab, LONDON, United Kingdom

In the context of studies using diffusion MRI, an important criterion to choose between the available diffusion metrics is the sensitivity to detect pathological changes. Sensitivity of diffusion metrics has been shown to vary widely across brain regions although the biological factors behind such variability remain undetermined. In this work we use computational simulations to evaluate the effect that different white matter configurations have on the sensitivity of existing metrics of diffusion and anisotropy. We show that for the same biological change, features of microstructural organisation like the angle of crossing fibres have a significant and characterising effect in the sensitivity of each particular metric.

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