Abstract #2090

Denoised diffusion spectrum imaging of white matter tracts in the brainstem

Cristina Granziera^1,2,3,4, Samuel St-Jean⁵, Alessandro Daducci³, Gunnar Krueger⁶, and Maxime Descoteaux⁷

¹Radiology, A.A. Martinos Center for Biomedical Imaging, Massachussetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²2. Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Féderale Lausanne (EPFL), Lausanne, Switzerland, ⁴Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, ⁵6. Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Siemens Medical Solutions USA, Inc., Boston, MA, United States, ⁷Sherbrooke Connectivity Imaging Laboratory (SCIL), University of Sheerbrooke, Sherbrooke, Canada

High-angular resolution diffusion (HARDI) MRI, like diffusion spectrum imaging-DSI, provides an attractive tool to investigate the complex white matter structure in the brainstem. However, due to the application of high b-values in the HARDI acquisition, the raw images are SNR limited (SNR<10). In this study, we applied a novel denoising alogorithm to low-SNR DSI data. Our results showed that Generalized Anisotropy maps and tractography seeding the periacqueductal grey matter, a small structure in the mesencephalon, match more accurately the underlying anatomy when applying the denoising algorithm.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.