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Abstract #2186

A hybrid-segmentation atlas method to construct the attenuation correction factor for human pelvic PET/MRI

Hiroshi Kawaguchi1,2, Tkayuki Obata2,3, Hiromi Sano2, Eiji Yoshida2, Mikio Suga4, Yoko Ikoma2, Yukari Tanikawa1, and Taiga Yamaya2

1Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 2Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan, 3Research Center for Charged Ion Therapy, National Institute of Radiological Sciences, Chiba, Japan, 4Center for Frontier Medical Engineering, Chiba University, Chiba, Japan

The current attenuation correction method for human pelvic PET/MRI contains several problems such that the attenuation due to bone is not considered and a specific MR imaging, intended for attenuation correction only, is needed. In this study, we proposed a method to generate the distribution of attenuation correction factors with considering the bone attenuation using diagnostic T1-weighted MRI for pelvic PET/MRI scanning. The proposed method is the hybrid of the tissue segmentation based on Gaussian mixture model and the non-liner registration of tissue probability to a subject image. The simulation results showed that attenuation correction using the proposed hybrid method reduced the error on PET image than the conventional method.

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