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Abstract #2224

Increased Signal Intensity of brain structures on unenhanced T1-weighted images following 35 or more GBCA administrations

Yang Zhang1,2, Yan Cao1, George Shih1, Elizabeth Hecht3, and Martin R Prince1,4

1Radiology, Weill Cornell Medical Center, New York, NY, United States, 2Radiology, Qilu Hospital, Shandong University, Jinan, China, People's Republic of, 3Columbia University, New York, NY, United States, 4Radiology, Columbia University, New York, NY, United States

In 16 patients with 35 or more linear GBCA administrations increased T1 signal on unenhanced images was observed in dentate nucleus (100%), globus pallidus (100%), cerebral peduncles (100%), substantial nigra (88%), red nucleus (88%), colliculi (81%), posterior thalamus (75%), superior cerebellar peduncle (56%), internal capsule (50%), head of caudate nucleus (31%), body of caudate nucleus (25%) , whole thalamus (25%), pons (13%), anterior commissure (13%), posterior brain stem (6%), pituitary gland (6%), mammillary body (6%) and putamen (6%). The source of T1 signal increase is unknown but may relate to GBCA administration. No clinical significance was identified.

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