Abstract #2239

Sugar free tissue-mimicking MRI phantoms for improved signal-to-noise ratio

Carlotta Ianniello^1,2, Ryan Brown¹, Martijn Cloos³, Qi Duan⁴, Jerzy Walczyk³, Graham Wiggins³, Daniel K Sodickson^2,3, and Riccardo Lattanzi^2,3

¹Radiology, Center for Advanced Imaging Innovation and Research (CAI2R) and Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ²The Sackler Institute of Graduate Biomedical Science, New York University School of Medicine, New York, NY, United States, ³Center for Advanced Imaging Innovation and Research (CAI2R) and Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ⁴Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, MD, United States

We investigated Polyvinylpyrrolidone (PVP) as an alternative to sugar to control relative permittivity in tissue-mimicking MR phantoms. We constructed a two-compartment phantom filled with water solutions of PVP and NaCl, the latter used to control conductivity. A lower amount of PVP than sugar is required, allowing low permittivity materials to be realized. While signal decreases rapidly in sugar-based phantoms, PVP materials have long T₂^*/T₂, making PVP-based phantoms suitable for the validation of MR-based electrical properties mapping techniques that rely on high SNR of signal and B₁⁺ maps. PVP solutions are relatively inexpensive, easy to mix and do not require preservatives.

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