Abstract #2251

An assessment of the repeatability and sensitivity of T2 mapping in low-grade cartilage lesions at 3 and 7 Tesla

Vladimir Juras^1,2, Laurent Didier³, Vladimir Mlynarik¹, Pavol Szomolanyi¹, Stefan Zbyn¹, Nicole Getzmann³, Joerg Goldhahn³, Stefan Marlovits⁴, and Siegfried Trattnig^1,5

¹Department of Biomedical Imaging and Image-Guided Therapy, High Field MR Centre, Medical University of Vienna, Vienna, Austria, ²Department of Imaging Methods, Institute for Measurement Science, Bratislava, Slovakia, ³Novartis Institutes for Biomedical Research, Basel, Switzerland, ⁴Department of Traumatology, Medical University of Vienna, Vienna, Austria, ⁵Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

An assessment of the reliability of T2 mapping was achieved with a 3D-TESS sequence in patients with cartilage lesions ICRS Grade I-II. Since low-grade cartilage lesions are not usually accompanied by collagen matrix remodeling, we tested the sensitivity of T2 to detect these lesions at 3 and 7T. It seems that the reproducibility of 3T T2 mapping is higher than that of 7T; however, the sensitivity of T2 mapping for the detection of low-grade cartilage lesions was greater at the ultra-high field. T2 mapping could be used in the future as a good alternative to cartilage biopsies in future clinical trials on new therapies aimed at cartilage regeneration.

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