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Abstract #2278

Noninvasive Evaluation of Foot Oxygen Extraction Fraction with Multi-shot Asymmetric Spin Echo Method

Fei Gao1, Chengyan Wang2, Rui Zhang1, Xiaodong Zhang3, Kai Zhao3, Jue Zhang1,2, Xiaoying Wang2,3, and Jing Fang1,2

1College of Engineering, Peking University, Beijing, China, People's Republic of, 2Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of, 3Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of

In this study, a multi-shot ASE sequence with 32 varied echo shifts was implemented to acquire the source images for foot muscle OEF quantification. Three healthy volunteers (mean age 23 ± 1 years, range 22-24) were recruited to undergo the imaging of the foot using a 3.0-T whole-body scanner. The OEF and R2' maps indicate the feasibility of the proposed multi-shot ASE sequence in quantifying foot muscle OEF. These results hold promise for some clinical uses, for example, to study vascular function in peripheral artery disease.

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