Abstract #2278

Noninvasive Evaluation of Foot Oxygen Extraction Fraction with Multi-shot Asymmetric Spin Echo Method

Fei Gao¹, Chengyan Wang², Rui Zhang¹, Xiaodong Zhang³, Kai Zhao³, Jue Zhang^1,2, Xiaoying Wang^2,3, and Jing Fang^1,2

¹College of Engineering, Peking University, Beijing, China, People's Republic of, ²Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of, ³Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of

In this study, a multi-shot ASE sequence with 32 varied echo shifts was implemented to acquire the source images for foot muscle OEF quantification. Three healthy volunteers (mean age 23 ± 1 years, range 22-24) were recruited to undergo the imaging of the foot using a 3.0-T whole-body scanner. The OEF and R2' maps indicate the feasibility of the proposed multi-shot ASE sequence in quantifying foot muscle OEF. These results hold promise for some clinical uses, for example, to study vascular function in peripheral artery disease.

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