Abstract #2280

A simplified method to determine tissue-water T2 from CPMG image data in fat infiltrated skeletal muscle: application in the forearm in Duchenne muscular dystrophy

Nick Zafeiropoulos¹, Valeria Ricotti², Matthew Evans^1,3, Jasper Morrow³, Paul Matthews⁴, Robert Janiczek⁵, Tarek Yousry^1,3, Christopher Sinclair^1,3, Francesco Muntoni², and John Thornton^1,3

¹Neuroradiological Academic Unit, UCL Institute of Neurology, London, United Kingdom, ²Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom, ³MRC Centre for Neuromuscular Diseases, London, United Kingdom, ⁴Imperial College London, London, United Kingdom, ⁵GlaxoSmithKline, London, United Kingdom

A simplified CPMG signal decay model was used to determine muscle-water T2 (T2m) in fat-infiltrated skeletal muscle, using a predetermined mono-exponential approximation to the fat decay component. This approach enabled the stable estimation of T2m in the forearm muscles of non-ambulant Duchenne muscular dystrophy patients and healthy controls from a multi-echo CPMG acquisition with only 12 echo-times. Values obtained were in good agreement with previous reports, and largely independent of muscle fat content.

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