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Abstract #2280

A simplified method to determine tissue-water T2 from CPMG image data in fat infiltrated skeletal muscle: application in the forearm in Duchenne muscular dystrophy

Nick Zafeiropoulos1, Valeria Ricotti2, Matthew Evans1,3, Jasper Morrow3, Paul Matthews4, Robert Janiczek5, Tarek Yousry1,3, Christopher Sinclair1,3, Francesco Muntoni2, and John Thornton1,3

1Neuroradiological Academic Unit, UCL Institute of Neurology, London, United Kingdom, 2Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom, 3MRC Centre for Neuromuscular Diseases, London, United Kingdom, 4Imperial College London, London, United Kingdom, 5GlaxoSmithKline, London, United Kingdom

A simplified CPMG signal decay model was used to determine muscle-water T2 (T2m) in fat-infiltrated skeletal muscle, using a predetermined mono-exponential approximation to the fat decay component. This approach enabled the stable estimation of T2m in the forearm muscles of non-ambulant Duchenne muscular dystrophy patients and healthy controls from a multi-echo CPMG acquisition with only 12 echo-times. Values obtained were in good agreement with previous reports, and largely independent of muscle fat content.

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