Constantinos Anastasopoulos1,2, Melissa Hooijmans1, Jedrek Burakiewicz1, Andrew G. Webb1, Janbernd Kirschner2, Jan J.G.M. Verschuuren3, Erik H. Niks3, and Hermien E. Kan1
1Gorter Center, Leiden University Medical Center, Leiden, Netherlands, 2Pediatric Neurology and Muscle Disorders, University Clinic Freiburg, Freiburg, Germany, 3Department of Neurology, Leiden University Medical Center, Leiden, Netherlands
interpretation of muscle T2 relaxation times in muscular dystrophies is complicated by the disease
progression, as both inflammation and increased fat content result in a longer T2.
We measured water-T2 in two muscles of the lower leg using
a tri-exponential fitting of the T2 decay in patients with DMD and healthy
controls. We found a significantly higher T2-heterogeneity in the soleus muscle of patients, with no significant difference between the two groups in average
T2 values. T2-heterogeneity
should be taken into consideration when using the water T2 of the diseased
muscle as an outcome measure for therapeutic interventions.