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Abstract #2301

Structural and Biomechanical Properties of Hypertrophic Articular Cartilage Using Microscopic Magnetic Resonance Imaging

David J Kahn1, Daniel Mittelstaedt1, and Yang Xia1

1Physics and Center for Biomedical Research, Oakland University, Rochester, MI, United States

High-resolution T2 imaging of AC is able to quantitatively measure depth-dependent features of articular cartilage (AC). When the cartilage articular surface (AS) is oriented normal (0°) to the external magnetic field, healthy AC takes on a laminar appearance that indicates the superficial zone (SZ), transitional zone (TZ), and radial zone (RZ), where collagen fibers are oriented parallel, random, and perpendicular to the AS [1]. When the AS is oriented at the magic angle (55°), the nuclear dipolar interaction is minimized and the tissue appears homogeneous. Compression of AC has effects that change many zonal properties [2,3], and hypertrophy may alter the biomechanical function and depth-dependent collagen ultra-structure of AC.

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